The 40:1 ratio: why it actually matters in an inositol supplement.

Every inositol supplement on the shelf tells you it contains Myo-inositol and D-Chiro-inositol. Very few tell you the ratio — and the ratio is the entire study.

In healthy plasma, the body maintains roughly 40 parts Myo-inositol to 1 part D-Chiro-inositol. In women with PCOS, that balance shifts. Clinical work over the last decade has consistently found that supplementing at the physiological 40:1 ratio restores ovulatory cycles more reliably than Myo alone, and far more reliably than higher D-Chiro loads.

Products that quietly use 2:1 or 10:1 aren't wrong — they're cheaper. D-Chiro is roughly forty times the price of Myo. Formulating to physiology costs more per bottle, which is why so few brands do it.

OvaSync is dosed at 2,000 mg Myo + 50 mg D-Chiro per serving. Exactly 40:1. Exactly what the trials used.